Fry's brother Yancy's death from Futurama. It's not a regular death from some other shows where the protagonists have to witness the death of their friends. It's a death of which Fry has long known but doesn't care until he finds out his lucky four-leaf clover had been stolen by Yancy. Given the constant quarrels and fights between the two brothers in their childhoods, Fry naturally thinks Yancy did that out of the hatred for him. However, it turns out Yancy only found the clover by accident and gave it his son. He even named his son for his uncle because he loved Fry and had always been missing him ever since Fry's accident. Actually, this is the scene that made me fall in love with Futurama. Just like The Simpsons, these shows always have sad but also sweet moments that make me feel so emotional.