The only one I've heard used very much is weirdo. It means an eccentric person or one whose appearance is strange or weird. You would say, "He is a weirdo". But it wouldn't be be a usual thing for an adult to say. It would be more like something a kid would say about another kid.

Never seen or heard of biggo and smallo but lame-o is an insult used to talk about someone who is uncool or unoriginal e.g. "he has terrible trainers. What a lame-o". This is a bit outdated now but still used with the younger generation in the UK. Weirdo is used quite regularly in the UK too among all ages (I use this word everday :-) ), the definition is the same as Lisa has stated above. Hope this helps?