¿Que quiere decir "It is really itchy!" en Español?
「めっちゃかゆい！」ってスペイン語でなんて言うんでしょうか？

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'Pica mucho', something is giving you a rash and you must scratch yourself

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I agree with Kylecito but in some latinamerican countries it refers to a person or a thing that is very annoying to us.
Bye.

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Like Kylecito's answer, "It's really itchy" means just "pica mucho", " es muy picante", more related to skin than meals (chile, spicy foods, etc.)
Like Teresa said, it also means something you feel very uncomfortable with, like bugs, clothes, annoying people, etc.