Yes, the others have answered. I'll just add a few more examples. He gets really uptight when you mention politics. (This guy has strong opinions probably. I suspect he does not like politics and politicians, or a particular regime. He's probably not nervous - just bad-tempered or tense.) He gets really nervous when you mention the police. (This guy possibly has done something wrong, so he is in fear of the police). Of course, you can be nervous AND uptight.

For me, "uptight" can be used to describe a personality trait or for behaviour seen typically in certain situations. e.g. He often gets uptight if you mention money. It's difficult to talk to him about it. I think it's because he doesn't earn as much as he feels he should. When someone is uptight, they normally have a certain fixed view or feeling about something which makes them act consistently nervously.

Uptight means "Anxious or angry in a tense and overly controlled way". Example: He is very uptight about his daughter being a lesbian but he tries to hide his anger. "Nervous" has different meanings: (1) easily alarmed and agitated; (2) apprehensive... Example: He is nervous about the exam. Example: The war veteran is still suffering from post-trauma symptoms and is very nervous all the time.