How should I use ‘不知何故’ when speaking Mandarin?
I know it means 'somehow', but I'm not sure if I can use it in the same way as 'somehow'.

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“不知何故”means "Don't know the reason",so when "somehow"means"for some reason",they are the same.
But when "somehow"means "by some means",its different from“不知何故”。

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知=知道
何=什么
故=原因
不知何故=不知道什么原因=不知道为什么=不知道怎么回事

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结婚前的几天，她的未婚夫不知何故突然失踪了。

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just mean "don't know why" “someway" or "why".you can think about when would  you use the word.you can use "不知何故"in the same way

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举个例子：
1他原本身体棒棒的，不知何故，现在他一病不起。
2他向来每会必到，不知何故，今天他未能参加会议。
3不知何故养鸡场的鸡一只接一只地快死光了，人们恐慌起来，说是要闹瘟疫了。
1,2, 不知何故相当but， although, however.3 不知何故相当于why

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