This is just a quick explanation so it's probably not comprehensive, but it should give you a general idea - usually we use "en" to replace expressions with "de."For example:
1) Que penses-tu du nouveau film de Luc Besson?
-> this could be rephrased as "Qu'en penses-tu?"
(du=de+le)
2) Vous parlez de ce qui s'est passé hier?
-Oui, nous en parlons.
3) Combien de biscuits est-ce qu'elle mange?
-Elle en mange trois, elle en mange plusieurs
(expression of quantity: She eats three of them, she eats many of them)
*You cannot use "en" to refer to people. For example:
"Ils parlent de la jolie fille" would become "Ils parlent d'elle."
In other words, you would use a disjunctive pronoun instead to replace "la jolie fille"