Yes, the “what is it about” construction is usually used in sarcasm or anger. The idea is that some idea should be simple to understand, but the person is acting like he/she does not understand it. Example: “What is it about the word ‘no’ that you don’t understand?”, means “I told you ‘no’ but you keep asking; stop it, ‘no’ means ‘no.’ “. Or, to a person walking their dog in a no dogs allowed area: “What is it about ‘no dogs allowed’ that you don’t understand?”