「迷惑（めいわく）です！！」 が一番近い表現だと思います。

- omae urusai yarou dana - urusaiyo (annoying, noisy) uttoushiiyo (weary, annoying) irairasurundayo (offensive, irritant, annoying) - you need polite phrase? urusaidesu anata wa uttoushiidesu anata ga iruto iraira shimasu

"uzai" is appropriate in this situation, I think. but it's a slang expression used by younger generation, so you can omit "wa" or "ga" when composing a sentence sot it fits the way you talk. Omae uzai. or Anta uzai. is OK. (omae or anta is an impolite expression of kimi or anata) As for "Mendou kusai", you cannot use it for people. (Some use it for that purpose though. like "Omae mendo kusai", but it's not so common.)

あなたはうっとうしい。 おまえうざい。(swear words)

annoying = 面倒くさい（めんどうくさい）