no they're not interchangeable actually. "in half" would be used as more of an adverb.
examples: I cut the apple in half for you ("cut" is the main verb, "the apple" is the direct object for that verb, "in half" is the adverb/adverbial describing how it was cut. / I work much closer to home and my travel time was cut in half
"in halves" or "halves" is a plural noun. the singular form would be "half"
Examples: I picked up the two halves of the log that i split for fire wood / I cut the apple in half so i'll take one of the halves and you can have the other half.