Hi Bhuiyan, it is based on an English saying, "If the shoe fits, wear it." The Big Bang writers have changed it to "If the lab room disposable cover fits." It's a bit hard to explain - if I said "People who smoke cigarettes are rude", and you said to me "But I smoke," then I could say to you "If the shoe fits". In other words, if what I have said applies to what you do, then admit it. Sorry, this is difficult to explain! :-)