Every railway line in Japan has 上り and 下り. Usually, 上り means to be bound for a capital. If the line is directly connected to Tokyo st. 上り is easy to say. But in other regions sometimes its difficult to say which direction is 上り even for native Japanese. You need to check train time tables.

My pleasure.

Okay, thank you!!

No, it's not. All trains leaving Tokyo are "下り".

So, from Tokyo to Hokkaido will NOT be "上り?"