Hello! "Investigations" implies that there is more than one person. For example, "Investigations into the crime took months to complete." "Investigation" is more neutral - it could be one person or many people. For example, "Upon further investigation, I discovered that my cat had eaten a sock." "The police investigation was inconclusive."
In your example sentence, it could be used like this: "I had an issue with sending a request to the endpoint, and after some investigation, I noticed what the issue was."
Hope that helps!
Emily