An abstract translated by myself Abstract: Gram-positive bacteria mainly causes acute bacterial skin and skin structure infection(ABSSSI） and bacterial respiratory infection. It widely exists in nature and also respiratory tract and surface of skin. With the immoderately using of antibiotics, much more strains with drug resistance have emerged. When the first time methicillin-resistant Staphylococci aureus(MRSA) had been isolated in British in the 50s of the previous century, it was just 2 years after clinical applying of methicillin. Despite the progressing of modern medicine, continuous emerging of strains with drug resistance keeps on bringing significant challenges to the research of restricting microbe. Therefore, it is always a well-concerned focus to exploit novel antibacterial agents. This essay summarizes some recent developments of researches about inhibiting gram-positive bacteria with artificial antibacterial compounds and semisynthetic antibiotics, while provide some information to related researchers.