I think it's a very good question and also not so easy one. I will just tell you my opinion and wait for the others opinion. In this case, I think Korean conversation doesn't go simply as English conversation. You say 'Thank you' and expect a proper answer 'You are welcome'. Many textbook would teach you to say '천만예요', but it's not so common in native Korean. I would say there is no such a formula. It depends on every different situations. So I would choose No.4 for both of your questions. If this is just a normal situation, I would answer as follows. 수고하셨습니다. --> 네, 감사합니다. 고생하셨어요 --> 아유, 아니에요. 감사합니다 --> 아니에요. well, I think I am pretty much choosing No.1 now. though I just said I would choose No.4 which doesn't make sense at all. I know. but uh, this is kinda hard to explain, because not only my English proficiency is not good enough but there could be many different accents making a different nuance. I realized this is a kind of tough question. I will just wait for the other native Korean to answer. Thanks for giving this question. Happy new year^^

1. response to 수고하셨어요 or 고생하셨어요 - 아니에요 ("안이예요" is a bad spelling) - 괜찮아요 - 뭘요 - 네 / 예 2. response to 감사합니다 - 아니에요 / (별거/아무것도) 아니에요 / 괜찮아요 - 뭘요 / 별말씀을요 - 감사하기는요 / 그런 말씀 마세요 / ... - 네 / 예 네/예 is a light acknowledgment which can be used in both situations. It just means "Yes" or "OK", but sounds appropriate if you use the right friendly tone.