Here, 則 means "then". 却 = "however".
目标远大则成就伟大 = When your sights are grand, THEN your achievement is worthy of admiration.
2018年11月3日
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we can't replace 则 with 却here. because 则,we use it when a good thing has a good influence or bad thing bad influence, as for 却, it's normally a optimistic condition but has a bad influence
2018年11月3日
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Agree with Jeff: that's means :then
2018年11月4日
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则 and 却 are not always interchangeable. 则 has many usages. Here, it is not used to show contrast. I could be wrong, but I'm fairly certain.