1、怎么是你?
When you encounter someone you're unexpected to see, you can say "怎么是你?" to show your surprise, or just implying a question "Why you are here ?". Anyway, this is an unfriendly sentence, showing the speaker's unwelcome attitude to that person.
2、怎么老是你?
“老” in this sentence means "again", emphasizing the speaker's disgust emotions.
In sum, all these sentence are very rude and unfriendly, I guess that's why the Chinese people have never said them to you.