Hi, everyone! :)
What difference between “a lot of” and “lots of”?
For example in sentences:
1.My uncle and aunt have a lot of money.
2.Nina has lots of clothes.

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Lots of is more informal than lot of.

I use them indistinctly usually

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There is hardly any difference really. Both are informal English, though "lots of" would be marginally more informal. Even more informal would be "loads of..."

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Thanks for the answer!