Is there a difference between the words "nexus" and locus"? As the question implies, I'm interested in only the semantical aspects of the two words I've listed. I've looked up these two words on some online dictionaries. After some searching, I've noticed these words share a common definition that expresses a similar meaning. Definitions, Meanings, & Spanish Translations | Lexico.com defines nexus as "the central and most important point or place: " Cambridge Dictionary defines locus as "the place where something happens or the central area of interest in something being discussed:" Here are some examples to expound my point: Example 1: For us, the island had become the locus of the struggle. Times Square is the nexus of the New York subway. Example 2: The real nexus of the money culture was Wall Street. The community is a locus of healing, not the hospital or the clinic. In each of these examples, “locus” and “nexus" refer to a place or locality as the cause or source of great activity.