"diaosi " it's mean someone (sepecial  youngman) not much money  ,not high education and not beautiful.who stayed at home all day playing video games, with dim prospects for the future -- in other words, a loser.It was coined first by single, young men who feel they have dead-end lives.

means loser

I think figuring out what 高富帅 means helps a lot ，cause its the opposite of 屌丝。
Beside，屌丝 is offen used in jest or self-mockery，so，it would be a little offensive to say someone is a 屌丝。