The basically mean the same thing. Where I live, it is more common to hear "What's wrong" if somebody is sad, sick, etc. "What's wrong with you?" is said normally when someone is being rude to you. However, they can almost be used interchangeably.

“What’s wrong with you” is a full on personal attack lol

avoid it at all cost

Watch out, Shu. “What’s wrong with you” can be extremely rude (as demonstrated by Marcelo). It can imply that the person you’re talking to is the *cause* of a problem and that they are faulty in some way.

Thank you, Andrew. I appreciate you.

what kind of question is that ? what´s wrong with you bro ?