"Is it happened again ?" vs "Did it happen again ?"
Do these sentence have same meaning ?

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"Is it happened...?" is WRONG.
The correct way:
Did it happen again?

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Magenta, thanks for your comment. Rosia, good point about present continuous form. I liked it. Thank you too.

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Magenta, thanks for your comment. Rosia, good point about present continuous form. I liked it. Thank you too.

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Magenta, thanks for your comment. Rosia, good point about present continuous form. I liked it. Thank you too.

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You can also say, "Is it happening again?", in the present continuous form.