你丫是北京方言的词汇,意思有点儿像美国人,朋友之间说,hey you sucker. 应该是你碰了不该碰的东西。手贱就是没管住自己的手,用手碰了、点了不该动的东西。
叫你丫手贱,有很强的幸灾乐祸的语气。你可以想想一个场景。
“Dude, don't touch it”
"eh, too late" then he's hurt or cursed, disappeared whatever not very good things happened to him.
"Told you"这句就有点儿像 叫你丫手贱