What does "screw you" mean?
I saw the phrase and want to know what it means (and also maybe how I can use it in a conversation).

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Errr... don't use it in a conversation.  It's a softer version of "f*ck you!"

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It means: piss off; get lost; fuck you

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That s word is just a little more "polite" than the f word. Actually the original meaning is "cheat", "cheat you", but, nobody would use "screw" instead of "cheat" nowadays.