If used as wish, I think it can be translated with "Abbi cura di te" or "Riguardati" or even, more generally, "Mi raccomando".
It can change in differents contexts, look here for further informations: http://www.wordreference.com/enit/take%20care =)
December 31, 2007
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As a "Goodbye", probably "Stammi bene" will fit the best ("Mi stia bene" is the formally equivalent).
January 1, 2008
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