Literally : Even if you talk to him/her a lot more and finally wear out(破) your mouth, 。。。。
It implies that there is no need to waste time, energy etc. persuading someone.
For example, if you want to attend a foreign school, company, but your mother don't want you to and speak a lot, Then your father may say 'Since she has made her mind, Even if you has worn out your mouth, she won't change that.'/'既然她已经下定决心,即使你说破了嘴,她也不会改变的.'
Sometimes you may also see these sentences, 即使你磨破了嘴皮/即使你说破了大天/即使你扯破了嗓子.