On BBC1 there is national news at 6pm every day. Then from 6:30 until 7 there is regional news. This differs depending on where you live in the country. For example, where I live, the regional news is called 'Look East'. In Yorkshire, where my father is from, it is 'Look North'. And so on. On ITV the situation is reversed. The local news is at 6:00 and the national news is at 6:30.
There is a Welsh language channel that you can see in England if you have a satellite dish, called S4C. In Wales, I don't know, but I would be very confident that there are Welsh language channels available. There are regional programming differences, yes. Just as one small example, in the north, a sport called 'rugby league' is very popular. There is a show there that broadcasts highlights of the games every week. I've seen it when I've visited my cousins. In the south and in the Midlands where I live, it isn't shown because there is much less interest.