What dose he look like?
What is he like?
I think your question is very interesting. Actually these English expression, "What does he look like?" and "What is he like?" are often combined in Japanese, saying "彼はどんな人ですか" that asks about his appearance and character. If you specifically want to ask about his looking, you can say, " 見た目はどんな人ですか” or "見かけはどんな感じですか”、but still, you might get response like " Well, he is tall and thin and he looks like a nice person." (背が高い、やせている。優しい人のようだ） Interestingly, if it's in a crime scene, a detective asks "What does the man look like?"(どんな男だ？) a witness would answer, "He has brown hair and blue eyes, tall and big）"(茶色い髪で目は青い。背が高く大きい）Answering about the personality is not needed in the case, I think.
Just mind this point, "what" of "what does he look like" should be translated どんな, not "なに”.
If you have any questions, I will be happy to help you. Just text me, please.