Grammatically, it can only be A, but the English is still not good.
It would be better written as either 'A particularly frustrating drawback of this book is . . ' or 'Frustratingly, a particular drawback of this book is . . '
Otherwise, use either 'particular' or 'frustrating' but not both words : 'A particular drawback of this book is . . ' / 'A frustrating drawback of this book is . . '.