How to describe if someone spoils the plot of drama?
If someone tells me the plot of a drama, but I haven't seen that drama, can I say "he/she does a spoiler to me" or "he/she spoils the plot to me"?
I don't know how to use "spoil" as a verb in this kind of situation, please kindly help me on this question. Thank you very much! :)

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I would advise using spoil as a verb, exactly as you do in your question. The suggestions using “spoiler” don’t sound natural. The exception is the phrase “Spoiler alert!” which is said to let others know that what you are about to say is going to contain spoilers. It gives them a chance to avoid having the plot spoiled for them.

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Don't spoil the film for me!  I want the ending to be a surprise.

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The verb uses regular definition 'to spoil' as in to ruin. So, "he spoiled the plot for me."  For the noun it would be something like "she told me a big spoiler"

It's quite hard to use this in the present. Maybe "She's spoiling the plot for me right now" but that's a bit of an odd thing to say

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You could say 'he/she gave away a spoiler'

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Note that the past tense of spoil can be spelt spoiled or spoilt. The latter is common in British English. She told me the ending - it really spoilt the movie for me.