Kate, to come up with ....can mean....to think of, or invent A pickup "line" is an introduction that a man uses to attract the interest of a woman when he first meets her. to come up with a line....to think of something to say when you meet a member of the opposite sex in order to to impress her. Examples of pickup lines: Can I take a picture of you, so I can show Santa just what I want for Christmas? If looks could kill, you would be a weapon of mass destruction. What does it feel like to be the most beautiful girl in this room? Chandler probably thought that the woman he was talking with was a lesbian, so there was no reason for him to come up with a line to impress her since she wouldn't be interested in him anyway.

Это было в одной из серий сериала "Друзья". Там Чендлер был на лесбийской свадьбе, где он подошёл к девушке и сказал эту фразу, после чего та развернулась и ушла

Someone was hitting on you?

А какой контекст?