Hello, Awais! The main difference between "nevertheless" and "in spite of" is their respective parts of speech. "Nevertheless" is an ADVERB (conjunctive adverb), while "in spite of" is a PREPOSITION. Their main similarity is that they both express CONTRAST between two points in a sentence. Conjunctive Adverbs connect two independent clauses. This means that the clauses can be separated by a semi-colon (;) or a period. For example: I woke up very late this morning; nevertheless, I arrived at the office on time. OR I woke up very late this morning. Nevertheless, I arrived at the office on time. The preposition, "in spite of" is always followed by a NOUN. For example: In spite of the heavy rain, we went out to play a soccer game. We went out to play a soccer game in spite of the heavy rain. You can also add "that fact that" after "in spite of" (i.e. "We went out to play a soccer game in spite of the fact that it rained very hard.") Hope this helps! :)

'Nevertheless' is an adverb, and it stands alone in a sentence. It can go at the beginning, middle or end of a sentence, usually separated from the rest of the sentence by a comma (,). Its meaning and use is similar to the word 'However'. 'In spite of' can't stand alone. It has to be followed by a noun, or a verb in the form of a gerund: In spite of my illness, .... In spite of being ill, ... It has the same meaning and use as the word 'Despite'.

Note: "Where DO we use.... ?" Pay attention to question forms. This is elementary grammar.