Placing "However" on a Sentence
Here is the two example sentences.

1. Adults learn languages differently in every period of life, however.

2. However, Adults learn languages differently in every period of life.

What is the difference between placing 'However'on the front and the bottom of a sentence.

Thank you in advance.

Question

Placing "However" on a Sentence
Here is the two example sentences.

1. Adults learn languages differently in every period of life, however.

2. However, Adults learn languages differently in every period of life.

What is the difference between placing 'However'on the front and the bottom of a sentence.

Thank you in advance.

Answer

Both are correct, although you need to have a lower case (small) letter 'a' for adults in the second sentence.
'However' can go at the beginning or end of a sentence. It can also go in a grammatically appropriate place part-way through a sentence. In all cases, it is important to get your punctuation and capitalisation right.

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Answer

You would never place "however" at the end of a sentence. However is a conjuctive adverb so it either starts a sentence or will connect two sentences.

Example 2 is the correct one.