There are examples: In spite the rain we enjoyed our holiday We went out in spite of the rain In despite spite of & in spite have the same meaning (although ) and there is no real different between them .. you should follow them with a noun You can put them in first / middle of the sentence too

We use both of these conjunctions when we want to communicate that one thing did not stop something else from happening. They are most commonly followed by a present participle (verb + ing). For example; Despite/In spite of...his bad attitude, he still got the job. Despite/In spite of...driving as fast as he could, he arrived late. Despite/In spite of...having bought extra food, they were hungry after the party. Despite/In spite of...not speaking any German, they really enjoyed the museum