For a native speaker, the difference is clear.
We use the present perfect for unfinished or 'open' periods of time:
1A - He has never traveled by train.
2A - I have never been to France.
In these sentences, we're talking about a person's life experience SO FAR, so the situation could change. For example, if your friend suggests a trip to France, you might say 'Great! I'd love to go. I've never been to France'. The option for me to go to France is still open - so we use the present perfect.
We use the past simple for finished or 'closed' periods of time:
1B - I never fell in love
2B - I never had a family
A person who says 'I never fell in love' is perhaps an old man who is talking about his youth. If he says this, it's clear that he feels that the period of life when he might have fallen in love is completely over. Or a 50-year-old woman would say 'I never had a family', because she is now too old to have children. If the situation cannot change, or if we feel the option for it to change is no longer available, we use the past simple.
We have to use a past tense form along with time markers like 'yesterday', 'last week' 'in 2005', six months ago, 'when I was a child', and so on, because these are finished periods. Sometimes we use the past simple when it's understood that the time period is finished. For example, if we're having a discussion about what happened at a party last night, this will be in the past tense because we know that the party isn't going on any more.
I hope that makes sense.