1. This is a lame joke. - this is a bad joke. it's not funny or its been told so many times that people are bored of it. 2. Lame guys. - this can mean many different negative things all kind of meaning 'not cool' Lame guys could be: -boring -rude or mean -lazy or unmotivated -unsuccessful -not romantic enough -annoying ... the list could go on forever.

Lame joke = bad joke. Lame guys = guys who girls would have extremely low interest in. Generally, “lame” means “bad” or “low quality.”