这件事情很麻烦 = This matter is quite annoying. 你这个人真麻烦 = You're so annoying.

“这件事很麻烦”最直接的说法用trouble、annoy、bother就可以了，在日常口语里能表达的就有很多，你可以说：Such a ticklish / sticky / knotty matter “你这个人真麻烦”在口语里你也可以说：U really get in my hair / U really get on my nerves / U'r such a pain to me等等 另外，nuisance这个词可以用来形容某件事或者某个人很烦人，用法是make oneself a nuisance 希望对你有点帮助吧

非常感谢你！Thanks a lot!

Plenty; pain in the ass, headache, annoying, bothering, disturbing, etc, etc.