Also Prakriti, in addition to Su Ki's excellent answers, one can use a State--of--Being verb, and write it this way: "What is the best way to enjoy being by yourself?" The answer of course, might begin with Reading, and in addition there are Fine Arts and Hobbies to follow. .

'Enjoy' needs to have an object. Perhaps you should rephrase this as something like: 'What is the best way to have fun by yourself?' or 'What is the best way to enjoy yourself when you're alone/ on your own?'.