You can say she is a housewife. If it is a male (whose wife works), then you would call him a househusband. The neutral term is homemaker. A housekeeper is a person who generally maintains and cleans a household. This means the person is an employee, and not the owner of the home.

a housekeeper is someone who gets paid to keep your house clean, similar to a maid. Where a housewife is the word for a wife who does not work outside the home (though she still does plenty to keep the house in order!)

I would not call her a housekeeper because according to wikipedia (http://en.wikipedia.org/wiki/Housekeeper_(servant), this is synonymous with servant. Some women do not mind being called housewives, or stay at home mums. Some find the term "housewife" condescending. Others may go for some interesting terms as evidenced in this post: http://answers.yahoo.com/question/index?qid=20100828101436AATMsWh I will not claim to know what any woman may prefer to be called, but If you had to choose between your two options, I'd say go for "Housewife" - and hope she doesn't mind.

Housewife is not an appropriate word because a woman cannot marry a house where she lives, she can only be a wife of her husband so the appropriate word is homemaker .