Is there a difference between Make a bet vs make bets?
"make[place, take] a bet" Is the same I think.

But I saw the sentence Leaders of large businesses sometimes "make huge bets" in expensive mergers and acquisitions.

When I look the word, bet in the dictionary, I can see make A BET not make BETS.

Is there a difference between Make a bet vs make bets?

Question

Is there a difference between Make a bet vs make bets?
"make[place, take] a bet" Is the same I think.

But I saw the sentence Leaders of large businesses sometimes "make huge bets" in expensive mergers and acquisitions.

When I look the word, bet in the dictionary, I can see make A BET not make BETS.

Is there a difference between Make a bet vs make bets?

Answer

Ever heard of singular and plural??

Answer

I want to place a bet on a horse race ,    ( one )    
I want to place some bets on a horse race  ( more than one )

Answer

I want to make a bet please. 
I like to make bets at John Bells betting shop.
If you make bets all the time you will have no money.
Try and make smaller bets rather than large bets then you may have more luck.