'Issue' as a noun has two main meanings: 1. It can refer to a copy of a regular publication, such as a newspaper. 2. It can mean a question, problem, topic or situation to be discussed.

The issue of food and blankets to flood victims; Have you seen the latest issue of the magazine; A new issue of commemorative stamps; The political issues; To issue forth to battle; I think it's enough

Could you tell us which examples confuse you?