There is a lot of very informal ways to say that you are pissed of. "Ça me soule", "ça me fait chier", "ça me casse les couilles", "ça m'emmerde", "ça me les brise", "j'en ai ras le bol", "j'en ai ras le cul", "j'en ai ras la casquette", "ça me vénère" (=ca m'énerve) etc. I like "ça me soule", as Hyejeong said.

So you want something really informal. We often use the slang expression "Tu m'as saoulé" (I've had enough of you). And if it's not someone but something that pissed you off, you say "Ça m'a saoulé", "Cette histoire m'a saoulé", etc.

Do you mean something like "Piss off" or in a sentence?