Does the inversion of a prepositional adverb influence the meaning of the sentence?
One slipper was nowhere to be found; the other had been laid hold of by an urchin, and off he ran with it
One slipper was nowhere to be found; the other had been laid hold of by an urchin, and he ran off with it

I wonder if there is a difference between "off he ran with it" and "he ran off with it".

Question

Does the inversion of a prepositional adverb influence the meaning of the sentence?
One slipper was nowhere to be found; the other had been laid hold of by an urchin, and off he ran with it
One slipper was nowhere to be found; the other had been laid hold of by an urchin, and he ran off with it

I wonder if there is a difference between "off he ran with it" and "he ran off with it".

Answer

They are both grammatically correct and have the same meaning. 
The first is only more poetic, more pleasing to the ear - and so you'll find it more in literature.

Thanks for asking!